The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

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The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

Researchers applied a topical gel containing CBD to rats with arthritis for 4 days. A 2020 review reports that CBD could have benefits for relieving chronic pain, improving sleep, and reducing inflammation, but that these effects are condition-specific. Different varieties of cannabis plants — such as hemp and marijuana — contain different levels of chemical compounds. CBD is an entirely different compound from THC, and its effects are very complex.

  • However, CBD, like almost all medications, also produces AEs and toxicity.
  • The exact reasons why CBD causes this effect are not fully understood, but some research suggests that CBD’s impact on the endocannabinoid system might affect how saliva is produced.
  • Natural Medicines disclaims any responsibility related to medical consequences of using any medical product.
  • Aside from the type of tissue, the concentrations of bioactive compounds in cannabis depend on variety, growth conditions, growing stage, harvest time and conditions of storage [3,41].

A study from 2018 found the ECS mainly responsible for modulating many metabolic processes, which start from the quantity of food ingested to the forms of food favored. These findings are featured in the peer-reviewed International Journal of Molecular Sciences (IJMS). As per the study, CB1 cannabinoid receptors can reduce body weight, whereas CB2 receptors can aid in not just browning white fats but also making thermic energy from chemical energy. Though more human studies are needed, CBD may benefit heart health in several ways, including by reducing blood pressure and improving artery function. High blood pressure is linked to higher risks of several health conditions, including stroke, heart attack, and metabolic syndrome.

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As cannabis is becoming legalized in various regions, research is gaining momentum and shows some promising results. People report using this oil for relief from pain, anxiety, depression, and sleep disorders. is cannabidiol addictive A different 2018 study, featured in the peer-reviewed journal ‘Pharmaceuticals’, looked to discover the pharmacological, cellular, and molecular logic behind cannabinoid receptors in body weight control.

If you’re hoping to reduce inflammation and relieve muscle and joint pain, a topical CBD-infused oil, lotion or cream – or even a bath bomb — may be the best option. Alternatively, a CBC patch or a tincture or spray designed to be placed under the tongue allows CBD to directly enter the bloodstream. Oral capsules of tetra-hydro-cannabinol (THC), cannabidiol (CBD) and their combination in peripheral neuropathic pain treatment.

6. Cardiovascular Complications of Diabetes

So, you cannot be sure that the product you buy has active ingredients at the dose listed on the label. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition. People taking high doses of CBD may show abnormalities in liver related blood tests. Many non-prescription drugs, such as acetaminophen (Tylenol), have this same effect. So, you should let your doctor know if you are regularly using CBD.

  • CBD modulates central nervous system (CNS) receptors such as CB1, CB2, serotonin 1A receptor (5-HT1A), TRPV1, and PPARγ, although it binds poorly to the THC-binding site on CB1 and CB2 cannabinoid receptors [10].
  • This is also considered a benefit for some people, but Jas Matharu-Daley, MD, a physician and chief medical officer for a CBD brand, notes that the effects might be too strong if you’re also taking CBD with other sedating medications.
  • Moreover, this compound is an agonist of GPR55, however this receptor does not mediate vasorelaxant response to Abn-CBD [150].
  • Here’s what you need to know about the research, benefits, and risks.

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